UN Women’s Mali Strategic Note 2020–2025 seeks to address gender inequalities exacerbated by political, social and security crises. Activities are clustered in the central and northern regions, including Bamako, Mopti, Timbuktu and Gao.

The programme prioritizes women's political participation, economic empowerment, peace and security, and combating gender-based violence. Approaches comprise supporting women's leadership platforms, promoting gender-responsive policies, and enhancing women's roles in peacebuilding and economic activities.  

Major partnerships involve the Government of Mali, Economic Community of West African States, African Union and civil society organizations. Significant outcomes comprise increased women's representation in peace committees and improved business environments for women. Strategic Note direct funding supports initiatives such as the Women’s Business Centre, which opens access to markets and financial services.